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Penicillin Cocktail: A close-up of the smoky, ginger-infused drink with a lemon twist.

Penicillin

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Penicillin Cocktail: Introduction

Penicillin Cocktail is a celebrated modern classic that has captivated palates worldwide with its unique blend of smoky, spicy, and sweet flavors. This invigorating drink offers a sophisticated twist on traditional whisky cocktails, making it a favorite among enthusiasts. Its complex profile provides a truly memorable drinking experience.

Crafting the perfect Penicillin Cocktail involves a careful balance of ingredients, each playing a crucial role in its distinctive character. From the robust base of Scotch to the zesty lemon and warming ginger, every component contributes to its harmonious taste. This guide will walk you through the essence of this remarkable beverage.

 

What is a Penicillin Cocktail?

This contemporary whisky-based drink is renowned for its intriguing combination of blended Scotch, fresh lemon juice, honey-ginger syrup, and a float of smoky Islay single malt Scotch. It presents a vibrant golden hue, often garnished with candied ginger or a lemon twist. The cocktail is typically served over ice in a rocks glass.

Penicillin is characterized by its layered flavor profile. Initial sips reveal a bright citrus tang, quickly followed by the comforting sweetness of honey and the invigorating kick of ginger. The distinctive smoky aroma and taste from the Islay Scotch float provide a captivating finish, adding depth and complexity to the drink.

 

The Science & Flavor

The Penicillin Cocktail masterfully balances several key flavor elements: sweet, sour, and smoky, with a spiced undertone. Fresh lemon juice provides the essential acidity, cutting through the richness and brightening the overall profile. This sour component is crucial for a well-rounded drink.

Honey-ginger syrup introduces both sweetness and a pungent, warming spice. Honey’s complex sugars interact with the whisky’s esters, while gingerol, the active compound in ginger, provides a delightful zing. The blended Scotch forms a robust base, offering malty and sometimes fruity notes, which are then dramatically enhanced by the phenolic compounds in the smoky Islay Scotch float. This final touch creates an aromatic top layer that elevates the entire sensory experience.

 

Origin & History

Penicillin – The iconic cocktail was created by acclaimed bartender Sam Ross in 2005 at the renowned Milk & Honey bar in New York City. Ross, a protégé of Sasha Petraske, was inspired to craft a whisky sour variation with a unique twist. He aimed to incorporate the warming, soothing qualities often associated with a “hot toddy” or a remedy for ailments, hence the name.

The drink quickly gained popularity within the craft cocktail scene and beyond, solidifying its place as a modern classic. Its innovative use of two types of Scotch, particularly the smoky Islay float, set it apart and showcased a creative approach to cocktail development. This particular cocktail remains a testament to modern mixology’s ingenuity. The rich history of Scotch whisky itself dates back centuries, with the first written mention in Scotland appearing in 1494.

 

Variations

While the classic Penicillin recipe is widely adored, there are several ways to explore its flavor profile through variations. The choice of blended Scotch can significantly alter the base, with some preferring a richer, bolder whisky while others opt for a lighter, fruitier expression. Experimenting with different brands allows for subtle shifts in the drink’s foundation.

The intensity of the ginger can also be adjusted by modifying the amount of ginger used in the syrup or by adding a small piece of fresh ginger to the shaker. Some enthusiasts might also explore different types of honey, such as wildflower or buckwheat, to introduce varying levels of sweetness and floral notes. For more tips on using honey in cocktails, resources are readily available. For a less smoky profile, the Islay Scotch float can be reduced or even omitted, though it is a signature element of Penicillin.

 

Food Pairings

The Penicillin Cocktail’s complex and robust flavor profile makes it an excellent companion for a variety of dishes. Its smoky notes and ginger spice pair wonderfully with rich, savory foods.

Grilled meats, such as slow-cooked pork ribs or a perfectly seared steak, work exceptionally well because the cocktail’s acidity and ginger cut through the richness of the meat, while the smoky Scotch complements the char. This drink also harmonizes beautifully with spicy Asian cuisine, particularly dishes featuring ginger, soy, and a touch of heat, as the cocktail’s ginger syrup echoes these flavors and the lemon provides a refreshing counterpoint. The benefits of ginger extend beyond flavor, offering digestive and anti-inflammatory properties. Finally, aged cheeses, especially those with a nutty or slightly pungent character, create a delightful contrast with the drink’s sweetness and smoke, offering a sophisticated pairing experience.

  • Total Time: 7 minutes
  • Yield: 1 1x

Ingredients

Scale
  • 45 ml Blended Scotch Whisky
  • 15 ml Islay Scotch (for float)
  • 20 ml Fresh Lemon Juice
  • 20 ml Honey-Ginger Syrup
  • Ice Cubes
  • Candied Ginger or Lemon Peel (for garnish)

Instructions

  1. To make honey-ginger syrup, combine 1 tbsp honey, 1 tbsp water, and 1/4 tsp grated ginger in a pan and warm for 2 minutes until thin – strain and cool.
  2. Add blended Scotch, lemon juice, and honey-ginger syrup into a shaker filled with ice.
  3. Shake briskly for about 20 seconds until the shaker feels cold to touch.
  4. Strain into an Old Fashioned glass filled with fresh ice cubes.
  5. Gently pour the Islay Scotch over the back of a spoon to float it on top – creating that signature smoky layer.
  6. Optional Garnish: Add a slice of candied ginger or a thin lemon peel twist.
  7. Optional: Use smoky honey for depth or replace Islay Scotch with a dash of peated whisky essence.
  • Prep Time: 7 minutes
  • Category: Cocktail
  • Cuisine: Modern Classic

Nutrition

  • Calories: 180

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